Endocrine Abstracts

Introduction: Opioids are commonly used for the treatment of pain, and their effects on the HPA (hypothalamic pituitary adrenal) axis may be under-recognised. In the present, a few non-systematic studies have investigated the effects of opioids on the HPA axis, but results have been conflicting. To our knowledge, there is only another case report of secondary adrenal insufficiency due to tramadol therapy, resulted in suppression on the HPA axis. We present the case of a 79 yea...

Background: Few previous studies suggested a negative impact of obesity on anti-Mullerian hormone (AMH) serum levels in patients with decreased ovarian reserve, but the data regarding the relationship between AMH and adiposity in the same category of patients without severe excess of body weight are scarce.Aim: The aim of the study was to evaluate the relationship between AMH serum levels and BMI in normal weight and overweight patients with reduced ovar...

IntroductionGrowth hormone deficiency (GHD) is a rare disorder and severe forms of GHD may have a genetic basis. Familial isolated growth hormone deficiency (IGHD) is classified into 4 types, type IA being the most severe form. These patients present with severe growth failure with undetectable growth hormone (GH) concentrations and about 50% tend to develop antibodies on GH treatment.(1, 2, 3) The appearance of anti-GH antibodies may not be a regular fi...

IntroductionBoth vitamin D insufficiency and multinodular goiter (MNG) are widespread throughout the world, with Romanian population being no exception. However, at this point in time there is insufficient data whether there is a connection between the two or is it just a coincidence. The aim of this study is to evaluate whether there is a relationship between serum level of 25-hydroxyvitamin D (25OHD) and the risk of differentiated thyroid cancer (DTC) ...

Beta-thalssaemia major (BTM) is a rare disease that encompasses a vast range of endocrinological complications, despite of the improvement of treatment protocols. The aim of this study was to identify the clinical and hematological parameters associated with osteoporosis, a frequent complication found in beta-thalassaemia patients.Patients with BTM were evaluated in the Endocrinology Department of Elias Hospital between February 2004 and March 2016. Only...

It was suggested that polycystic ovary syndrome (PCOS) patients have an increased risk for autoimmune thyroid disease. However the mechanisms underlying this association are incompletely clarified. The aim of the present study is to evaluate the factors associated with thyroid autoimmunity in patients with PCOS. We performed a retrospective study which included 126 PCOS patients (mean age 24±4.5 years, mean body mass index, BMI 27±7.33 kg/sqm) diagnosed based on Rott...

Background: Previous studies suggested that treatment with somatropinum in children with GH deficiency (GHD) may alter lipid profile and pituitary–thyroid axis function. However, results are divergent and data regarding a possible association between changes of thyroid function and of circulating lipids are scarce. The aim of this study was to report the changes of the lipid profile in children with GHD treated with somatropinum and the relationship between thyroid functi...

Introduction: Both TSH and prolactin serum levels within normal range were previously reported to be associated with metabolic parameters.Aim: To analyse the connections between serum levels of prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients.Material and methods: 322 PCOS patients (mean age 24.3±5.16 years and mean BMI 28±7.57 kg/m2) with normal serum prolactin and without thyroid d...

Introduction: Insulin-like growth factor 1 (IGF-1) is an established serum marker for both diagnosis of growth hormone (GH) deficiency and for monitoring treatment with Somatropin, whether it is recommended for the classic GH-insufficient short stature cases or for other GH-sufficient disorders.Aim: To evaluate whether serum level of IGF-1 at diagnosis has a predictive value for the response to somatropin treatment during the 2 years of treatment in chil...

Introduction: Vitamin D is a hormone essential for calcium absorption and bone mineralization, which is positively associated with bone mineral density. The aim of our study was to evaluate the relationship between 25-OH vitamin D values and parameters of bone mineralization (bone mineral density - BMD) and bone quality (trabecular bone score - TBS) in patients from day to day clinical practice.Materials and methods: We evaluated 433 postmenopausal women...